What does the AE query loop actually cost your institution?
Put in your own trial count, your own visit schedule and your own salary bands. The model shows the coordinator and PI hours your current AE workflow carries, and what those hours cost you across a year.
Three steps. About ninety seconds. Transparent formulas. Free report.
This page models your labour. Every assumption is on the page and every one of them is yours to change, with the literature behind each default cited alongside it. If you want to know what Burna costs, ask us in the meeting and we will tell you.
per-query minutes drive the largest share of total cost
Institution type *
Estimate if unsure. Typical ranges: community 5-30, AMC 40-150, NCI 250-600.
Optional. We estimate 0.25 FTE per trial if left blank.
Optional. We estimate 0.15 FTE per trial if left blank.
Ballpark across the portfolio. If unknown, we estimate 40 AEs per trial per year.
Oracle ClearTrial benchmark: 3,000-10,000 queries per oncology trial over its lifetime. We annualize the midpoint at ~3,250 per active trial-year.
Current AE grading approach *
$11.38M
annual AE workflow labor cost
= 132,342 clinical hours per year
Numbers update as you type. Most institutions discover queries are the biggest line.
every slider is conservative, move them to see the impact
For an academic medical center with 85 active trials:
Your estimated annual AE workflow labor cost
$11.38M
That is 132,342 clinical hours per year on AE grading, attribution, IND narratives, and the monitor query loop that follows. Most of it is the query loop.
What the math looks like at scale.
The monitor query loop drives most of this number, ahead of the initial grade. Oracle ClearTrial 2021 puts the per-query cost in the same range, and the benchmarks below show how it scales.
$0.8-2.4M
Community oncology, around 25 active trials.
$6-14M
Mid-sized AMC, around 80 active trials.
$40-60M
NCI comprehensive, around 400 active trials.
Sources: Oracle ClearTrial 2021; Pronker et al. 2011, BJCP; NCI public benchmark data.
RTM billing: patient self-reporting as reimbursable care.
Remote Therapeutic Monitoring (CPT 98976 / 98977 / 98980) is reimbursable by CMS when patients self-report symptoms. Healthnotes enables this with minimal coordinator overhead.
$0.32M
Assumes 680 active trial patients, 80 percent RTM eligibility, and full 12-month enrollment. CMS 2025 national averages.
These codes overlap with RPM and CCM billing rules. Talk to your compliance team before claiming. We can share a reference memo.